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KMID : 0811720180220060661
Korean Journal of Physiology & Pharmacology
2018 Volume.22 No. 6 p.661 ~ p.670
Fimasartan attenuates renal ischemia-reperfusion injury by modulating inflammation-related apoptosis
Cho Jang-Hee

Choi Soon-Youn
Ryu Hye-Myung
Oh Eun-Joo
Yook Ju-Min
Ahn Ji-Sun
Jung Hee-Yeon
Choi Ji-Young
Park Sun-Hee
Kim Chan-Duck
Kim Yong-Lim
Abstract
Fimasartan, a new angiotensin II receptor antagonist, reduces myocyte damage and stabilizes atherosclerotic plaque through its anti-inflammatory effect in animal studies. We investigated the protective effects of pretreatment with fimasartan on ischemia-reperfusion injury (IRI) in a mouse model of ischemic renal damage. C57BL/6 mice were pretreated with or without 5 (IR-F5) or 10 (IR-F10) mg/kg/day fimasartan for 3 days. Renal ischemia was induced by clamping bilateral renal vascular pedicles for 30 min. Histology, pro-inflammatory cytokines, and apoptosis assays were evaluated 24 h after IRI. Compared to the untreated group, blood urea nitrogen and serum creatinine levels were significantly lower in the IR-F10 group. IR-F10 kidneys showed less tubular necrosis and interstitial fibrosis than untreated kidneys. The expression of F4/80, a macrophage infiltration marker, and tumor necrosis factor (TNF)-¥á, decreased in the IR-F10 group. High-dose fimasartan treatment attenuated the upregulation of TNF-¥á, interleukin (IL)-1¥â, and IL-6 in ischemic kidneys. Fewer TUNEL positive cells were observed in IR-F10 compared to control mice. Fimasartan caused a significant decrease in caspase-3 activity and the level of Bax, and increased the Bcl-2 level. Fimasartan preserved renal function and tubular architecture from IRI in a mouse ischemic renal injury model. Fimasartan also attenuated upregulation of inflammatory cytokines and decreased apoptosis of renal tubular cells. Our results suggest that fimasartan inhibited the process of tubular injury by preventing apoptosis induced by the inflammatory pathway.
KEYWORD
Apoptosis, Fimasartan, Inflammatory cytokine, Ischemia reperfusion injury
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